Phosphoaspirin (MDC-43) a novel benzyl ester of aspirin, inhibits the Essay

Phosphoaspirin (MDC-43) a novel benzyl ester of aspirin, inhibits the growth of human cancer cells - Essay Example This study by Zhao, Mackenzie, Murray, Zhang, and Rigas (2009) aims to observe the anticancer activity and mechanism of the new phosphoaspirin (MDC-43). For the purpose of this study, several reagents were purchased, or gifted, from different pharmacological companies. Cell cultures were grown in the laboratory in line with the American Type Culture Collection instructions. The trypan blue exclusion method was used to measure the cell viability and growth. Moreover, the cell cycles were analyzed following standard PI protocols (Zhao, Mackenzie, Murray, Zhang, and Rigas 2009, p. 512). Human cancer cells derived from colon, pancreas, breast, liver and lung were used in this study; these are some of the major and most common forms of cancer and account for around â€Å"54% of all new cases of cancer in the USA† (Zhao, Mackenzie, Murray, Zhang, and Rigas 2009, p. 517). All cell lines that were studied showed that Phosphoaspirin was more powerful than aspirin in preventing cancer cell growth (Zhao, Mackenzie, Murray, Zhang, and Rigas 2009, p. 513). Moreover, phosphoaspirin was also shown to stimulate the creation of reactive oxygen species (Zhao, Mackenzie, Murray, Zhang, and Rigas 2009, p. 514). The study also observed that phosphoaspirin had an inverse effect on thiol levels in the cells, and produced intrinsic apoptosis (Zhao, Mackenzie, Murray, Zhang, and Rigas 2009, p. 514-516). Furthermore, the phosphoaspirin also increased cell signaling in some cells, however, the effect was limited to protein activation alone (Zhao, Mackenzie, Murray, Zhang, and Rigas 2009, p. 516). The data collected by the study clearly demonstrated that phosphoaspirin has a strong reduction effect on human cancer cells. Moreover, the effect is stronger than that of aspirin, as well as being more generalized. The strength of phosphoaspirin was found to be more uniformly superior to ordinary aspirin; however, no reason

How the Internet has Changed the way we live Essay

How the Internet has Changed the way we live - Essay Example Department of Defense gave birth to ARPANET which later became the internet. The visionaries who saw great potential in using computers to share information on research in scientific and military fields laid the spark of internet's birth. In 1962, J.C.R. Licklider of MIT proposed a global network of computers. Leonard Kleinrock developed the packet switching which is the basis of internet connections. In 1965, Lawrence Roberts connected a Massachusetts computer with a Californian one over dial-up telephone lines. The ARPANET, first brought online in 1969, initially connected four computers at universities in southwestern US. Ray Tomlinson, in 1972, brought e-mail to ARPANET. He was the one who introduced the symbol-@- to connect the username and address. The internet was designed to provide a communication network that would resist nuclear attacks. The early users were computer experts, engineers, scientists and librarians. During the '60s and '70s, Frederick G. Kilgour of the Ohio College Library Center led networking of Ohio libraries. In the mid 1970s, New England, the southwest states, Mid Atlantic states, etc. joined it to form national, later, international networks. The ARPANET matured in the '70s due to the TCP/IP architecture proposed and developed by Bob Kahn and Vint Cerf. USENET was born in 1979 with the Unix to Unix Protocol invention. Newsgroups were introduced to exchange information throughout the world. Though it was not a significant part of the Internet (due to the lack of TCP/IP), it played a vital role in the development of the Internet. BITNET appeared in1981 and it connected the mainframes of IBM and also provided mail services. SCNET, developed in 1984, grew into NSFNet, the backbone of Internet. In 1986, when it was developed, it gave access to a number of super computing centers. More departments started making use of the Internet. Hence, more tools and resources were needed. More universities, organizations and libraries got connected and Internet became harder to track. In 1991, the first friendly interface to the Internet was developed. In July, 1992, Delphi, the first national commercial online service offered Internet access to its subscribers. In 1993, Microsoft Internet Explorer was developed. With the release of Windows 98 which the browser well integrated in the desktop, Bill Gates capitalized on the Internet. The Internet Boom The impact of the Internet is too enormous that it takes a lifetime to elaborate on it. Business entered the Internet arena. Advertising showed up to attract consumers. Online shopping entered a faster pace. Consumers found it easy when they could compare prices. Delphi's free offer of web pages, chat rooms, community building centers, etc. made the Internet more and more on demand. High-speed connections spread. Cable modems and digital subscriber lines replaced the older, slower ones. Wireless access bloomed. Now, we even have small, portable devices that can be used to access the Internet like, the pocket PC, game machines, GPS devices, etc. Let us discuss how Internet affects the various fields of our day to day lives. IMPACTS ON BUSINESS In the beginning, the use of Internet remained to searching and mailing. With the rise of more innovations, people started applying technology to various fields. Business is one such field which was rewritten by the entry of Internet. ECONOMY We saw the days when anything was